Mother Seton Regional High School is a four-year girls' Catholic regional high school of the Archdiocese of Newark. Its diverse community represents a multi-ethnic, religious and socio-economic community. Its modern two-level building is located on a well-landscaped campus of 27 acres. It contains three science laboratories and two main computer rooms. The school has white board and SMART board technology available to all classrooms. The building is wireless networked, the Library/Media Center and all classrooms have internet accessibility. 

A spacious art studio as well as foods and clothing laboratories provide pleasant areas for instruction in fine and related arts for all students. A chapel, cafeteria and a large gymnasium and fitness center complete the facilities. The grounds are equipped with three tennis courts, a softball field and soccer field.